Metallic nanoformulations: Green synthetic approach for advanced drug delivery
DOI:
https://doi.org/10.18063/msacm.v2i1.729Keywords:
Nanotechnological, Silver nanoparticles, Reduction, Green synthesis, Antibacterial, Anticancer.Abstract
An important reason for investigation using plants for nanotechnological research is due to their easy availability as well as applications in various ailments. Silver nanoformulation can be synthesized using whole plant extract or bioactive of that particular plant. In addition, plant extracts or bioactive of the plant may act both as reducing agents and stabilizing agents in the synthesis process of nanoformulation. The therapeutic effect of plant extract is hindered because of its instability, poor solubility, and low bioavailability. So, nowadays, researches have been carried out for improving all these properties including sustainability through silver nanotechnological approach. The major advantage of green synthesis using plant extracts is that, organic solvents and other excipients are not used because the plant phytochemicals are involved directly in the reduction of the ions and formation of silver nanoparticles. The present review provides an updated knowledge on mechanism of green synthesis of silver nanoparticle and their mechanism of action as antibacterial and anticancer activities.References
Kumar B, Smita K, Seqqat R, et al. In vitro evaluation of silver nanoparticles cytotoxicity on Hepatic cancer (Hep-G2) cell line and their antioxidant activity: Green approach for fabrication and application. Journal of Photochemistry and Photobiology B: Biology 2016; 1(159): 8–13.
Tran QH, Le AT, et al. Silver nanoparticles: Synthesis, properties, toxicology, applications and perspectives. Advances in Natural Sciences: Nanoscience and Nanotechnolog 2013; 14(4–3): 033001.
Tagad CK, Dugasani SR, Aiyer R, et al. Green synthesis of silver nanoparticles and their application for the development of optical fiber based hydrogen peroxide sensor. Sensors and Actuators B: Chemical 2013; 5(183): 144–9.
Iravani S, Korbekandi H, Mirmohammadi SV, et al.. Synthesis of silver nanoparticles: Chemical, physical and biological methods. Research in Pharmaceutical Sciences 2014; 9(6): 385.
Mariselvam R, Ranjitsingh AJ, Nanthini AU, et al. Green synthesis of silver nanoparticles from the extract of the inflorescence of Cocos nucifera (Family: Arecaceae) for enhanced antibacterial activity. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2014; 129: 537–541.
Dhand V, Soumya L, Bharadwaj S, et al. Green synthesis of silver nanoparticles using Coffea arabica seed extract and its antibacterial activity. Materials Science and Engineering: C 2016; 1(58): 36–43.
Edison TJ, Sethuraman MG. Instant green synthesis of silver nanoparticles using Terminalia chebula fruit extract and evaluation of their catalytic activity on reduction of methylene blue. Process Biochemistry 2012; 47(9): 1351–7.
Roopan SM, Madhumitha G, Rahuman AA, et al. Low-cost and eco-friendly phyto-synthesis of silver nanoparticles using Cocos nucifera coir extract and its larvicidal activity. Industrial Crops and Products 2013; 43: 631–5.
Khalil MM, Ismail EH, El-Baghdady KZ, et al. Green synthesis of silver nanoparticles using olive leaf extract and its antibacterial activity. Arabian Journal of Chemistry 2014; 7(6): 1131–1139.
Gopinath V, MubarakAli D, Priyadarshini S, et al. Biosynthesis of silver nanoparticles from Tribulus terrestris and its antimicrobial activity: a novel biological approach. Colloids and Surfaces B: Biointerfaces 2012; 96: 69–74.
Saxena A, Tripathi RM, Singh RP. Biological synthesis of silver nanoparticles by using onion (Allium cepa) extract and their antibacterial activity. Digest Journal of Nanomaterials and Biostructures 2010; 5(2): 427Dig J Nanomater Bios432.
Prakash P, Gnanaprakasam P, Emmanuel R, et al. Green synthesis of silver nanoparticles from leaf extract of Mimusops elengi, Linn. for enhanced antibacterial activity against multi drug resistant clinical isolates. Colloids and Surfaces B: Biointerfaces 2013; 108: 255–259.
Das J, Das MP, Velusamy P. Sesbania grandiflora leaf extract mediated green synthesis of antibacterial silver nanoparticles against selected human pathogens. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2013; 104: 265–270.
Singh M, Kumar M, Kalaivani R, et al. Metallic silver nanoparticle: A therapeutic agent in combination with antifungal drug against human fungal pathogen. Bioprocess and Biosystems Engineering 2013; 36(4): 407–415.
Jacob SJ, Finub JS, Narayanan A. Synthesis of silver nanoparticles using Piper longum leaf extracts and its cytotoxic activity against Hep-2 cell line. Colloids and Surfaces B: Biointerfaces 2012; 91: 212–214.
Sankar R, Karthik A, Prabu A, et al. Origanum vulgare mediated biosynthesis of silver nanoparticles for its antibacterial and anticancer activity. Colloids and Surfaces B: Biointerfaces 2013; 108: 80–84.
Jeyaraj M, Rajesh M, Arun R. An investigation on the cytotoxicity and caspase-mediated apoptotic effect of biologically synthesized silver nanoparticles using Podophyllum hexandrum on human cervical carcinoma cells. Colloids and Surfaces B: Biointerfaces 2013; 102: 708–717.
Dipankar C, Murugan S. The green synthesis, characterization and evaluation of the biological activities of silver nanoparticles synthesized from Iresine herbstii leaf aqueous extracts. Colloids and Surfaces B: Biointerfaces 2012; 1(98): 112–119.