Call-for-Papers
2018-09-11
Whioce Publishing Pte Ltd and the Editor-in-chief invite all authors to submit their manuscripts to our newly launched journal, Genetic Disease Study, for peer review.
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Clinical and genetic backgrounds of hypertrophic cardiomyopathy with mid-ventricular obstruction
2018-09-11Hypertrophic cardiomyopathy (HCM) is characterized by unexplained left ventricular hypertrophy. This study aimed to reveal the clinical and genetic backgrounds of the unique HCM with mid-ventricular obstruction (HCM-MVO) subtype. We identified 34 patients with HCM-MVO in our cohort, and about half (47%) of these patients experienced adverse events. We analyzed 67 cardiomyopathy-associated genes in the patients. In total, 44% of patients with HCM-MVO carried the cardiomyopathy-associated genetic variant (CAGV) in 14 genes. Only 21% of patients carried HCM-associated CAGVs in major sarcomere-encoding genes, while 18% of patients carried CAGVs in dilated cardiomyopathy/arrhythmogenic right ventricular cardiomyopathy-associated genes. CAGVs were more frequent in patients with asymmetric septal hypertrophy (ASH) than in those without ASH. These findings suggest that HCM-MVO is a high-risk group and may have different etiologies from typical HCM. Read more about Clinical and genetic backgrounds of hypertrophic cardiomyopathy with mid-ventricular obstruction -
Therapy-induced small-cell disease: from mouse to man and back
2017-06-08With the emergence of increasingly potent androgen deprivation therapy, rates of treatment-emergent small-cell neuroendocrine prostate cancer are increasing. In a recent prospective study, Aggarwal and colleagues defined the frequency and clinical and genomic characteristics of these tumours.
Read more about Therapy-induced small-cell disease: from mouse to man and back
